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When correcting blindness in mice, researchers at Columbia University found that though CRISPR did manage to successfully edit the particular gene responsible for blindness, it also caused mutations to more than a thousand other unintended genes. The off-target effects of CRISPR have long been known, but this new research highlights just how extensive they can be, and highlights the importance of research to understand them.

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Already, there are two clinical trials using CRISPR in humans underfoot in China, and a US trial is slated to begin sometime in the next year. Predictive algorithms are used to identify areas likely to be affected by off-target DNA mutations, and refinements to the technology suggested that in those trials off-target effects would be few.

Researchers looked at mice that they had previous corrected a gene associated with blindness in, sequencing their entire genome to hunt for changes.

While they found that CRISPR had indeed successfully corrected the desired gene and restored vision to forex capital markets llc new york mice, two different mice had undergone more than 1, unintended mutations, as well as more than deletions and insertions of genes researchers did not aim to affect.

None of those changes had been predicted by their computer algorithm.

Unwanted mutations to genes are always potentially harmful—genetic diseases like the blindness they were trying to cure is, after all, one such european stock market predictions. While every medical treatment has side effects, this new research underscores that whole genome sequencing will be crucial to understand just what kinds of side effects might occur as we begin to use CRISPR more frequently.

In the torrent binary options strategy for videos, though, it seems like all of those research dollars being funneled into perfecting CRISPR may be money well spent.

Video Sploid Paleofuture io9 Science Reviews Field Guide. CRISPR May Not Be Nearly as Precise as We Thought.

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A New Flavor of CRISPR Could Tackle Some of the Worst Genetic Diseases. You may also like.

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